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The journal takes the premise that innovative approaches — including gene therapy, cell therapy, and epigenetic modulation — will result in clinical interventions that alter the fundamental pathology and the clinical course of age-related human diseases. With the changing emphasis from genetic to epigenetic understandings of pathology including telomere biology , with the use of gene delivery systems including viral delivery systems , and with the use of cell-based therapies including stem cell therapies , a fatalistic view of age-related disease is no longer a reasonable clinical default nor an appropriate clinical research paradigm.

Papers must be clear and concise, but detailed data is strongly encouraged. The journal publishes research articles, reviews, communications and technical notes.

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